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ISSN: 2161-0444

Medicinal Chemistry
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Special Issue Article

New Perspectives in Cancer Therapy: The Biotin-Antitumor Molecule Conjugates

Giuseppe Tripodo1#, Delia Mandracchia2, Simona Collina1*, Marta Rui1 and Daniela Rossi1#

1Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy

2Department of Pharmacy, University of Bari “Aldo Moro”, Via Orabona 4, 70125 Bari, Italy

#Giuseppe Tripodo and Daniela Rossi contributed equally to this work

*Corresponding Author:
Simona Collina
Department of Drug Sciences
University of Pavia
Viale Taramelli 12, 27100 Pavia, Italy
Tel: +39 (0) 382987379
E-mail: [email protected]

Received date: March 18, 2014; Accepted date: April 21, 2014; Published date: April 23, 2014

Citation: Tripodo G, Mandracchia D, Collina S, Rui M, Rossi D (2014) New Perspectives in Cancer Therapy: The Biotin-Antitumor Molecule Conjugates. Med chem S1:004. doi: 10.4172/2161-0444.S1-004

Copyright: © 2014 Tripodo G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Chemotherapy is still the first-line treatment of cancer, even if drugs currently used in therapy generally possess high toxicity and poor selectivity. In the last two decades several efforts have been made to overcome these drawbacks by specifically carrying anticancer drugs to the tumors. Among the different approaches, the so called vitaminmediated drug targeting has recently emerged as a novel and valuable strategy. Indeed, the linkage of cytotoxic drugs to selected vitamins, leading to vitamin-drug conjugates, would result in specifically delivering great amounts of the targeted drug at high doses to cancer cells. Among vitamins, biotin seems to be the most promising targeting agent. The aim of this review is to get an overview on recent success in the conjugation of biotin with molecules endowed with anticancer properties.

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