alexa New Perspectives in Tolerance Induction for Vascularized Composite Allotransplantation | OMICS International | Abstract
ISSN: 2161-1076

Surgery: Current Research
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Mini Review

New Perspectives in Tolerance Induction for Vascularized Composite Allotransplantation

Jeng-Yee Lin1 and Shuen-Kuei Liao2*

1 Division of Plastic Surgery, Department of Surgery, Taipei Medical University Hospital, and Medical College, Taipei Medical University, Taipei, Taiwan

2 Graduate Institute of Cancer Biology and Drug Discovery and Center of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan

*Corresponding Author:
Shuen-Kuei Liao
Taipei Medical University
250 Wu-Hsing St., Taipei 11031, Taiwan
Tel: +886-0912-753-715
E-mail: [email protected]

Received date: April 29, 2014; Accepted date: June 11, 2014; Published date: June 13, 2014

Citation: Lin JY , Liao SK (2014) New Perspectives in Tolerance Induction for Vascularized Composite Allotransplantation. Surgery Curr Res 4:196. doi: 10.4172/2161-1076.1000196

Copyright: © 2014 Lin JY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Although transplantation of Vascularized Composite Allografts (VCA) has become a clinical reality, complications resulting from long-term immunosuppression remain major barriers to broader indication. Ideally, induction of tolerance has been considered the Holy Grail in both solid organ and VCA transplantation. Recent advances in immunomodulatory medication and cell-based therapy exploiting donor bone marrow (BM) cells, regulatory T cells (Tregs) and mesenchymal stem cells have opened exciting opportunities for tolerance induction in VCA transplantation. This mini-review focuses on current understanding of these drugs and cell-based immunomodulatory strategies and their role(s) in tolerance induction for VCA transplantation.

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