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ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
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New Techniques for the Study of Neural Tube Defects

Yunping Lei1 and Richard H Finnell1,2*
1Dell Pediatric Research Institute, Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas
2Dell Children’s Medical Center, Austin, Texas
Corresponding Author : Richard H. Finnell
Departments of Nutritional Sciences and Chemistry
The University of Texas at Austin, Dell Children’s Medical Center
1400 Barbara Jordan Blvd Austin, Texas, USA
Tel: 512-495-3001
E-mail: [email protected]
Received: December 02, 2015 Accepted: December 19, 2015 Published: December 26, 2015
Citation: Lei Y, Finnell RH (2015) New Techniques for the Study of Neural Tube Defects. Adv Tech Biol Med 4:157. doi:10.4172/2379-1764.1000157
Copyright: © 2015 Lei Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Neural tube defects (NTDs) are among the most common complex congenital malformations observed in newborns. When the neural tube fails to close completely, severe malformations of the brain and/or spinal cord and subsequent neurologic impairment occurs. It is widely believed that nutritional, environmental and genetic interactions contribute to NTDs. It is well established that low folate levels during pregnancy increases a mother’s risk of having pregnancy complicated by an NTD, and providing periconceptional folate supplementation reduces this risk. The underlying genetic mechanisms of NTDs are still unclear. We review the many new approaches to better understand the etiology, especially the genetic etiology, underlying this family of birth defects.

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