alexa New Validated Spectroscopic Method for the Simultaneous Estimation of Simvastatin and Sitagliptin.
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

New Validated Spectroscopic Method for the Simultaneous Estimation of Simvastatin and Sitagliptin.

Sujani PV1*, Y Padamanabha Reddy2, N Devanna3, SS Phanindra1 and P Anasuya4

1Department of Pharmaceutical Analysis, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Medak (dt), Andra Pradesh, India

2Raghavendra Institute of Pharmaceutical and Educational Research, Anantapur, Andra Pradesh, India

3Department of Chemistry, JNTU-College of Engineering, Anantapur, Andra Pradesh, India

4Department of Pharmacokinetics, Mylan India, Andra Pradesh, India

*Corresponding Author:
Sujani PV
Department of Pharmaceutical Analysis
Procadence Institute of Pharmaceutical Sciences
Rimmanaguda, Medak (dt), Andra Pradesh, India
Tel: +91 9642435074

Received: 08/10/2013 Accepted: 29/11/2013



A new, simple, sensitive, rapid, economic, UV Spectroscopic method was developed for the estimation of Simvastatin-Sitagliptin in Pure and Tablet dosage forms. The differences in solubilities of drugs were used for the estimation by extracting them into individual solvents. The linearity for Simvastatin was found between 6-20 μg/ml and between 10-50 μg/ml for Sitagliptin. Simvastatin showed the maximum absorbance at 232nm & Sitagliptin at 246nm and Validation parameters like Precision, Accuracy, and System suitability parameters were determined and examined by applying validated parameters.


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