Newfangled Quantitative Pharmacia (Isradipine) Stratagem: Quality by Design (Qbd) Taguchi Array via Response Surface (L25 Via CCD20) Methodology
- *Corresponding Author:
- Vikash Kr
P. D. Memorial College of Pharmacy
Sector-3A; Sarai Aurnagabad, Bahadurgarh, India
E-mail: vikasruhilo1 @gmail.com; rajeevkharb_2007 @rediffmail.com
Received Date: May 20, 2015; Accepted Date: August 21, 2015; Published Date: August 24, 2015
Citation: Kumar V, Kharb R (2015) Newfangled Quantitative Pharmacia (Isradipine) Stratagem: Quality by Design (Qbd) Taguchi Array via Response Surface (L25 Via CCD20) Methodology. Pharm Anal Acta 6:411. doi: 10.4172/2153-2435.1000411
Copyright: © 2015 Kumar V. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Statistically (L25 via CCD20), a novel array via response surface analytical process was an attempt to develop a quantification of the pharmacies/bulk, Isradipine using organic medium (methanol & chloroform) as solvent. During analysis, the maximum absorption wavelength of model drug was found at lambda max 327nm and also done its recovery via validation further. In the beginning, by using a quality improvement statistically array looms (Taguchi) was generated numerous level/space (s) of the independent variable (A=methanol; B=chloroform & C=ratio of A: B) by performing experimentally (L25 array runs to studied their response to be found the finer spaces). Additionally, a three-dimensional response surfaces strategy [RSM; three dimensional central composite designs (CCD20)] explored variables non-factorial levels which are used as fine. Also, responses quadratic (02nd order) equation of response (Y=absorption) was predicted analytically for “finer to finest” (2.5 to 15μg/ml) by analysis alone variable space as well as together. Thus, newfangled Beer’s finest in-terms of linearity, precision, sensitivity and accuracy during analysis range was found and also validated for further, finest determination. As well, economically inexpensive quantitative can be titled as newfangled analytical estimation of Isradpine (CCBs; Calcium channel blocker) in bulk/Pharmacia forms.