alexa Next Generation Antibacterial Hydroxyapatite Coating: A

Bioceramics Development and Applications
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Research Article

Next Generation Antibacterial Hydroxyapatite Coating: Antibacterial Activity of Ag Ions in Serum

I. Noda,1* F. Miyaji,1 Y. Ando,1,2 H. Miyamoto,2 T. Shimazaki,3 Y. Yonekura,3 M. Miyazaki,3 M. Mawatari,3 and T. Hotokebuchi3

1Research Department, Japan Medical Materials Corporation, Osaka 532-0003, Japan

2Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan

3Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan

*Corresponding Author:
I. Noda
E-mail: [email protected]

Received date: 11 November 2010; Accepted date: 2 December 2010



We developed a novel thermal spraying technology for a silver-containing hydroxyapatite (Ag-HA) coating with antibacterial activity to reduce the incidence of implant-associated infections. In this study, we determined the concentration of Ag ions that show antibacterial activity in fetal bovine serum (FBS) and antibacterial activity of the Ag-HA coating in FBS. The minimum inhibitory concentration (MIC) of Ag ions for several bacteria in FBS was in the range of 4.0–7.9 ppm. When 10 ppm Ag were added (as AgNO3 solution), 0.01 ppm of free Ag ions was detected. As the MIC of Ag ions approached the concentration that enabled formation of free Ag ions in FBS, the antibacterial activity of added Ag can be attributed to the free Ag ions. The Ag-HA coating showed strong antibacterial activity in FBS as well; the Ag concentration in FBS was 26 ppm for the antibacterial test of the Ag-HA coating. Because the Ag-HA coating can release sufficient free Ag ions in FBS, we observed that the Ag-HA coating shows a strong antibacterial effect in the biological medium studied.


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