alexa NFAT Signaling and Bone Homeostasis | OMICS International | Abstract
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Review Article

NFAT Signaling and Bone Homeostasis

Chen S1Pan M2*
1Shanghai Jiao Tong University Affiliated Xin Hua Hospital, Department of Medical Oncology, Shanghai, China
2Department of Medical Oncology and Hematology, Kaiser Permanente Medical Center, Santa Clara, CA, USA
Corresponding Author : Minggui Pan
Department of Medical Oncology and Hematology, Kaiser
Permanente Medical Center, CA, USA
Tel: 408-851-4306
Fax: 408-851-4319
E-mail: [email protected]
Received January 03, 2013; Accepted February 25, 2013; Published February 28, 2013
Citation: Chen S, Pan M (2013) NFAT Signaling and Bone Homeostasis. J Hematol Thromb Dis 1: 102. doi: 10.4172/2329-8790.1000102
Copyright: © 2013 Chen S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Bone homeostasis is a function of the constant balancing acts between osteoclasts and osteoblasts, regulated by numerous factors in cellular and molecular levels. Calcineurin-NFAT pathway plays critical roles in bone homeostasis by regulating many aspects of bone development and remodeling. NFATc1 is the master transcription factor of osteoclasts, acting downstream of RANKL (receptor activator of nuclear factor-κB ligand) to control osteoclastogenesis. NFATc1 also plays important role in osteoblastogenesis, its increased nuclear occupancy in osteoblasts causes osteopetrosis by regulating chemokine and Wnt pathways. Targeting NFAT pathway may provide therapeutic avenues for treating bony disorders.

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