alexa Nicotinamide Phosphoribosyltransferase in Human Diseases
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

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Research Article

Nicotinamide Phosphoribosyltransferase in Human Diseases

Li Qin Zhang1, Daniel P. Heruth1 and Shui Qing Ye1,2*

1Department of Pediatrics, Children’s Mercy Hospitals and Clinics, University of Missouri School of Medicine, Kansas City, MO 64108, USA

2Department of Biomedical and Health Informatics, Children’s Mercy Hospitals and Clinics, University of Missouri School of Medicine, Kansas City, MO 64108, USA

*Corresponding Author:
Dr. Shui Qing Ye, MD, PhD
Departments of Pediatrics
Children’s Mercy Hospitals and Clinics
University of Missouri-School of Medicine
2401 Gillham Road, PRC/4th FL
Kansas City, MO 64108
E-mail: [email protected]

Received Date: November 15, 2010; Accepted Date: December 07, 2010; Published Date: January 07, 2011

Citation: Zhang LQ, Heruth DP, Ye SQ (2011) Nicotinamide Phosphoribosyltransferase in Human Diseases. J Bioanal Biomed 3: 013-025. doi: 10.4172/1948-593X.1000038

Copyright: © 2011 Zhang LQ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Nicotinamide phosphoribosyltransferase (NAMPT) was first reported as a pre-B-cell colony enhancing factor in 1994 with little notice, but it has received increasing attention in recent years due to accumulating evidence indicating that NAMPT is a pleiotropic protein such as a growth factor, a cytokine, an enzyme and a visfatin. Now, NAMPT has been accepted as an official name of this protein. Because of NAMPT’s multiple functions in a variety of physiological processes, their dysregulations have been implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis. This review will cover the current understanding of NAMPT’s structure and functions with an emphasis on recent progress of nicotinamide phosphoribosyltransferase’s pathological roles in various human diseases and conditions. Future directions on exploring its Terra incognita will be offered in the end.

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