alexa NKT Cell Subsets and Proinflammatory Cytokine Changes in Mice as a Result of a Natural <em>Pasteurella pneumotropica</em> Infection | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

NKT Cell Subsets and Proinflammatory Cytokine Changes in Mice as a Result of a Natural Pasteurella pneumotropica Infection

Yawei Liu and Shohreh Issazadeh-Navikas*
Neuroinflammation Unit, Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200 Denmark
Corresponding Author : Shohreh Issazadeh-Navikas
Professor, Neuroinflammation Unit
Biotech Research & Innovation Centre (BRIC)
University of Copenhagen, Denmark. Ole Maaløes Vej 5
DK-2200, Danish Biocenter, Copenhagen N, Denmark
Tel: +45-3532 5649
Fax: +45-3532 5669
E-mail: [email protected]
Received: December 15, 2011; Accepted: January 24, 2012; Published: January 28, 2012
Citation: Liu Y, Issazadeh-Navikas S (2012) NKT Cell Subsets and Proinflammatory Cytokine Changes in Mice as a Result of a Natural Pasteurella pneumotropica Infection. J Clin Cell Immunol 3:117. doi:10.4172/2155-9899.1000117
Copyright: © 2012 Liu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google

Abstract

CD1d-dependent natural killer T (NKT) cells play an important protective role in a variety of autoimmune, allergic, tumor, and infectious diseases, but there are several controversial reports. The balance in subsets of NKT cells and their activation status prior to induction of such diseases could play a critical role in the clinical outcome. Pasteurella pneumotropica is a commonly found bacterium in laboratory rodents. Because this infection is often asymptomatic and hence can go undetected, and given different levels of acceptable health status in different animal facilities, this infection could impact the outcome of reported scientific studies. We report that subclinical natural infection with P. pneumotropica significantly affects the balance among different subsets of NKT cells. While the major CD1ddependent population, i.e., CD4+ NKT cells, was not significantly affected by infection in wild-type (WT) or CD1d-/- mice, CD8+ NKT cells significantly increased in infected WT mice. Interestingly, double negative NKT cells, while significantly suppressed in WT mice due to infection, were unaffected in CD1d-/- mice. The pattern of proinflammatory cytokines IFN-γ and IL-17A considerably changed as a result of infection. The differential effects were even more pronounced when investigating different T-cell subsets and their cytokine profiles.
While the effect of infection on shaping immune cell balance could be expected, mice lacking CD1d- dependent NKT cells differed entirely in their response to a subclinical infection. This subsequently indicated influences of NKT cells on other T-cell subsets and their cytokine milieu. Collectively, these data confirm the importance of controlling environmental factors which could have strong impacts on immune balance, and consequently dictate the outcome of immune-mediated diseases.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7