alexa Nkx2-5 Regulates Tdgf1 (Cripto) Early During Cardiac Development | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Nkx2-5 Regulates Tdgf1 (Cripto) Early During Cardiac Development

Ann N. Behrens1, Yi Ren1, Anwarul Ferdous1,2, Daniel J. Garry1,2 and Cindy M. Martin1,2*
1Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA
2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Corresponding Author : Cindy M. Martin, MD
University of Minneapolis
420 Delaware St. S.E. MMC 508
Minneapolis, MN 55455, USA
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Received: July 13, 2012; Accepted: August 28, 2012; Published: August 28, 2012
Citation: Behrens AN, Ren Y, Ferdous A, Garry DJ, Martin CM (2012) Nkx2-5 Regulates Tdgf1 (Cripto) Early During Cardiac Development. J Clin Exp Cardiolog S11:003. doi:10.4172/2155-9880.S11-003
Copyright: © 2012 Behrens AN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Congenital Heart Disease (CHD) is the most frequent and deadly birth defect. Patients with CHD that survive the neonatal period often progress to develop advanced heart failure requiring specialized treatment including cardiac transplantation. A full understanding of the transcriptional networks that direct cardiac progenitors during heart development will enhance our understanding of both normal cardiac function and pathological states. These findings will also have important applications for emerging therapies and the treatment of congenital heart disease. Furthermore, a number of shared transcriptional pathways or networks have been proposed to regulate the development and regeneration of tissues such as the heart. We have utilized transgenic technology to isolate and characterize cardiac progenitor cells from the developing mouse heart and have begun to define specific transcriptional networks of cardiovascular development. Initial studies identified Tdgf1 as a potential target of Nkx2- 5. To mechanistically dissect the regulation of this molecular program, we utilized an array of molecular biological techniques to confirm that Nkx2-5 is an upstream regulator of the Tdgf1 gene in early cardiac development. These studies further define Nkx2-5 mediated transcriptional networks and enhance our understanding of cardiac morphogenesis.

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