alexa NMDA R/VDR in Fish Melanocytes; Receptor Targeted Therapeutic Model and Mechanism in Parkinsons disease
ISSN: 2167-7956

Journal of Biomolecular Research & Therapeutics
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Research Article

NMDA R/VDR in Fish Melanocytes; Receptor Targeted Therapeutic Model and Mechanism in Parkinsons disease

Olalekan OM1* and Olurotimi JS2

1Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria

2Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria

*Corresponding Author:
Ogundele OM
Department of Anatomy, College of Medicine and Health Sciences
Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
Tel: +2347031022702
E-mail: [email protected]

Received date: February 26, 2014; Accepted date: April 26, 2014; Published date: April 28, 2014

Citation: Olalekan O, Sanya OJ (2014) NMDA R/VDR in Fish Melanocytes; Receptor Targeted Therapeutic Model and Mechanism in Parkinson's disease. J Biomol Res Ther 3:114. doi: 10.4172/2167-7956.1000114

Copyright: © 2014 Ogundele OM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The observable trend in the concept of evolution creates a template that advanced cell types are evolved from rudimentary cells over time. This is evident in protein structure and function observed along the evolutionary trend. An important component of cell evolution involves the role of microtubules and other members of the conserved family of the cell cycle/division proteins that have shown consistency from the yeast to the Homo sapiens over a billion years. In this study, we used specific imaging technique to compare the structure of melanocytes by manipulating NMDA R and VDR; to foster the study of synaptic denervation and pigment loss observed in PD. This information is important, as careful analysis and guided extrapolation of data can yield results of transnational significance. The outcome from two separate studies shows that both NMDA R and VDR are involved in cellular process formation in a way that can be likened to adrenergic cell process formation. Thus suggesting a possibility of adopting this cell type as a model.

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