No Change in Brain-Derived Neurotrophic Factor Levels Following a Single Session of Light to-Moderate Intensity Walk in Chronic Stroke PatientsMariana Lacerda e Silva1, Viviane Aparecida Carvalho de Morais1, Renata Maria Silva Santos1, NatÃ¡lia Pessoa Rocha2, Paulo Pereira Christo3, Luci Teixeira Fuscaldi4, Aline Alvim Scianni4, AntÃ´nio LÃºcio Teixeira5 and Paula Luciana Scalzo6*
- *Corresponding Author:
- Paula Luciana Scalzo
Department of Morphology
Institute of Biological Sciences
Universidade Federal de Minas Gerais
Belo Horizonte MG, Brazil
E-mail: [email protected]
Received date: February 18, 2017; Accepted date: March 20, 2017; Published date: March 25, 2017
Citation: E Silva ML, De Morais VAC, Santos RMS, Rocha NP, Christo PP, et al. (2017) No Change in Brain-Derived Neurotrophic Factor Levels Following a Single Session of Light to-Moderate Intensity Walk in Chronic Stroke Patients. J Neurol Disord 5:334. doi:10.4172/2329-6895.1000334
Copyright: © 2017 E Silva, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Many studies show the beneficial effects of overground gait training in stroke patients. However, it is not know whether it is able to induce changes in brain-derived neurotrophic factor (BDNF) levels, which could positively influence neurophysiological mechanisms. Objective: To evaluate the effect of a single session of light-to-moderate intensity walk on BDNF serum levels and its precursors (proBDNF) in chronic ischemic stroke patients. Methods: Patients were asked to walk for 30 minutes in the target heart rate training zone (30-60% of maximal heart rate). Blood samples were collected immediately before and after a single session. Results: Fifteen individuals with 60.8 (7.7) years old participated of this study. There was no significant difference in proBDNF (p=0.573) and BDNF (p=0.563) serum levels between pre- and post-session. Conclusion: This study used light-to-moderate intensity because the goal is to approach the gait training in clinical setting. The lack of increase in BDNF levels can be explained by two reasons: the intensity zone of the heart rate selected during the session and not having a gradual increase in this intensity.