alexa No Evidence for Association Between the Functional rs18
ISSN: 2161-1068

Mycobacterial Diseases
Open Access

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Research Article

No Evidence for Association Between the Functional rs1862513 Polymorphism in the Promoter Region of the Resistin Gene (RETN) and Pulmonary Tuberculosis in Northern Spain

Ocejo-Vinyals JG1*, Escobio A2, Irure-Ventura J1, Ausín F1, Arroyo JL3, Agüero R4, and Fariñas MC5

1Immunology, Hospital Universitario Marqués de Valdecilla-IDIVAL,Santander, Spain

2Faculty of Biology, University of Oviedo, Spain

3Bank Regional Blood and Tissue, Cantabria, Spain

4Department of Pneumology, Hospital Universitario Marqués de Valdecilla, Santander, Spain

5Infectious Diseases Unit, Hospital Universitario Marqués de Valdecilla -University of Cantabria, Santander, Spain

Corresponding Author:
Ocejo-Vinyals JG
Immunology, Hospital Universitario Marqués de Valdecilla-IDIVAL
Santander, Spain
Tel: +34942202941
E-mail: [email protected]

Received Date: February 06, 2015; Accepted Date: February 27, 2015 ; Published Date: February 28, 2015

Citation: Ocejo-Vinyals JG, Escobio A, Irure-Ventura J, Ausín F and Arroyo JL et al. (2015) No Evidence for Association between the Functional rs1862513 Polymorphism in the Promoter Region of the Resistin Gene (RETN) and Pulmonary Tuberculosis in Northern Spain. Mycobact Dis 5:178. doi:10.4172/2161-1068.1000178

Copyright: © 2015 Ocejo-Vinyals JG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Elevated levels of circulating Resistin, a peptide hormone produced by adipocytes in rodents but also by monocytes and macrophages in humans, has been reported in patients with tuberculosis infection. To date, only a few studies mainly focused in conditions such as diabetes, obesity, and cardio-metabolic risk have treated to analyse the role of single nucleotide polymorphisms in the Resistin Gene (RETN). However, polymorphisms in this gene have not been previously tested in pulmonary tuberculosis susceptibility.

Methods: The rs1862513 (-420C>G), a functional polymorphism in the RETN gene, which has been found to increase circulating resistin levels, was analysed in 192 patients with pulmonary tuberculosis, all of them HIV negative, and in 245 healthy individuals from a well genetically conserved Spanish population.

Results: Significant differences in genotype and allele frequencies of the rs1862513 functional polymorphism were not observed between patients and normal controls.

Conclusion: Our results would indicate that RETN rs1862513 would not play a major role in the susceptibility to pulmonary tuberculosis at least in our population in a well-powered study.

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