alexa Non Cognitive Neuropsychiatric Impairments in Alzheimer’s Disease
ISSN: 2376-0281

International Journal of Neurorehabilitation
Open Access

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Research Article

Non Cognitive Neuropsychiatric Impairments in Alzheimer’s Disease

AV Medvedeva* and NN Yahno

Neurological Department of First Moscow Medical University, Moscow, Russian Federation

Corresponding Author:
AV Medvedeva
Neurological Department of First Moscow Medical University
Moscow, Russian Federation
Tel: +79165084008
E-mail: [email protected]

Received date: December 26, 2016; Accepted date: December 29, 2016; Published date: December 31, 2016

Citation: Medvedeva AV, Yahno NN (2016) Non Cognitive Neuropsychiatric Impairments in Alzheimer’s Disease. Int J Neurorehabilitation 3:241. doi:10.4172/2376-0281.1000241

Copyright: © 2016 Medvedeva AV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Alzheimer’s disease (AD) is one of the most frequent neurodegenerative disorders. AD is usually associated with non-cognitive neuropsychiatric impairment (NCNI) as apathy, depression, anxiety, emotional labiality, sleep disorders. Methods: 131 patients with AD (mild, moderate degree) were included in the investigation according to the diagnostic criteria of DSM IV and MKB 10. 45 AD patients were on galantamine, 43-memantin and 43-combined therapy. The control group includes 45 patients. In our investigation in the main group of AD patients the duration of the disease was from 6 months to 4.3 years, on average 3.3 years. Standard neuropsychological an investigation was performed in AD and control group which included the following tests- MMSE: Mini Mental State Examination, FAB: Frontal Assessment Battery), clock drawing test, 12 world list immediate and delayed recall (subscore, total). Neuropsychiatric investigation includes neuropsychyatric inventory (NPI-Cummings). Results: Correlation analysis between cognitive and non-cognitive neuropsychiatric impairments in combined group showed Total NPI-MMSE, r=-0.312, p=0.032; Total NPI-FAB, r=-0.41, p=0.03, Total NPI-FAB, r=-0.41 p=0.03, Apathy-12 world delayed recall (total), r=-0.45 p=0.001, Apathy-12 world learning test delayed recall with help r=-0.45 p=0.001, Sleep scale-12 word learning test immediate recall (r=+0.44 р=0.03, Sleep disorders-12 worlds learning test-delayed recall r=+0.55 р=0.001). Correlation between NPI and EEG data showed Total NPI-spectral power in Т3, r=+0.46 p=0.048, Depression-spectral power of delta in С3 r=+0.34 p=0.032, Depression-spectral power of theta band in С4 r=+0.32 p=0.032, Apathy-spectral power in theta band in С3, r=+0.37 р=0.01, Apathy-spectral power in theta band in С4 r=+0.33 p=0.031, Emotional liability-spectral power in delta F1 r=+0.47 р=0.027, Emotional liability-spectral power in F2 r=+0.46 p=0.049, Total NPI-intra hemispheric coherence of theta in Т3-T4 r=-0.45 p=0.048, Depression- Intra hemispheric coherence in С3-C4 r=-0.35 p=0.033, Аpathy-Intra hemispheric coherence in С3-С4 r=-0.45 p=0.048, Аpathy-Intra hemispheric coherence of theta in T3-T4 r=-0.32 p=0.03, Emotional liability-Intra hemispheric coherence in F1-F2 r=-0.46 р=0.026, Emotional liability-Intra hemispheric coherence in T3-T4 r=-0.47 p=0.048. Conclusion: There were found significant correlations between cognitive and non-cognitive neuropsychiatric impairments. So the data gives significant possibility to think that NCNI are the obligatory sign of AD.


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