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Non Infectious Cavitary Exogenous Lipoid Pneumonia: A Case-Based Short Review | OMICS International | Abstract
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
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Non Infectious Cavitary Exogenous Lipoid Pneumonia: A Case-Based Short Review

Laura Bivona1,2*, Micaela Romagnoli2,3, Sara Piciucchi4, Alessandra Dubini5, Angelo Carloni6, Vittorio Pietrangeli7, Raffaele Campisi8, Giuseppe Di Maria1,8 and Venerino Poletti2

1Pulmonology Unit, Policlinico “G. Rodolico”, Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy

2Pulmonology Unit, GB Morgagni-L Pierantoni hospital, Forlì, Italy

3Pneumologie, Pole Coeur-Poumons, CHU Montpellier, France

4Radiology Unit, GB Morgagni-L Pierantoni hospital, Forlì, Italy

5Pathology Unit, GB Morgagni-L Pierantoni hospital, Forli, Italy

6Radiology Unit, “S.Maria” hospital, Terni, Italy

7Pulmonology Unit, S. Camillo de Lellis hospital, Rieti, Italy

8Pulmonology Unit, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy

*Corresponding Author:
Laura Bivona, MD
Pulmonology Unit
Policlinico “G.Rodolico” – Università di Catania
Via Santa Sofia 78, 95123 Catania, Italy
Tel: +393209673976
E-mail: [email protected]

Received date: October 16, 2014; Accepted date: February 26, 2015; Published date: February 28, 2015

Citation: Bivona L, Romagnoli M, Piciucchi S, Dubini A, Carloni A, et al. (2015) Non Infectious Cavitary Exogenous Lipoid Pneumonia: A Case-Based Short Review. J Pulm Respir Med 5:242. doi: 10.4172/2161-105X.1000242

Copyright: © 2015 Bivona L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Lipoid pneumonia (LP) is due to the accumulation of either endogenous or exogenous lipids in the alveoli. The exogenous LP (ELP) results from the chronic aspiration or inhalation of animal, vegetable, or mineral oils or fatty substances that by reaching the pulmonary alveoli cause a foreign body-type inflammatory reaction of lung parenchyma, associated with fibrosis, necrosis, and possible cavitation. Pulmonary reaction is characterised by symptoms and radiological findings that are common to other pulmonary diseases. The radiologic presentation of ELP includes lung consolidations and ground-glass opacities, with predominant involvement of the lower lobes. Thickening of interlobular septa, adipose or not adipose single mass, and poorly marginated nodules may also occur. Cavitation, when present, is mainly associated with infection by non-tuberculous mycobacteria or fungi. Thus in patients exposed to lipoid aspiration presenting with cavitated mass on CT scan, possible infection should be thoroughly ascertained, and adequate treatment promptly initiated. Hereby, we report three cases of non-infectious cavitary exogenous lipoid pneumonia. In all three patients, one with acute onset and two with chronic recurrent form, the ELP diagnosis was confirmed by both cytological and histological findings, whereas microbiological examination gave negative results. Moving from these three cases, we review the pathogenesis, clinical and radiological manifestation of ELP.