Nonclassically Secreted Regulators of AngiogenesisIgor Prudovsky*
Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
- *Corresponding Author:
- Igor Prudovsky
Maine Medical Center Research Institute
81 Research Drive
Scarborough, ME 04074, USA
E-mail: [email protected]
Received February 04, 2013; Accepted February 25, 2013; Published February 28, 2013
Citation: Prudovsky I (2013) Nonclassically Secreted Regulators of Angiogenesis. Angiol 1:101. doi:10.4172/2329-9495.1000101
Copyright: © 2013 Prudovsky I. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Many secreted polypeptide regulators of angiogenesis are devoid of signal peptides. These proteins are released through nonclassical pathways independent of endoplasmic reticulum and Golgi. In most cases, the nonclassical protein export is induced by stress. It usually serves to stimulate repair or inflammation in damaged tissues. We review the secreted signal peptide-less regulators of angiogenesis and discuss the mechanisms and biological significance of their unconventional export.