alexa Non-Coding RNAs: A Dynamic and Complex Network of Gene
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
Open Access

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Research Article

Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation

Munshi A1, Mohan V2,3* and Ahuja YR2

1Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad-500016, India

2Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Khairatabad, Hyderabad 500004, India

3Research Unit, Hansgene Cancer Foundation, Hyderabad, 500004, India

*Corresponding Author:
Vasavi Mohan
Vasavi Medical and Research Centre
Department of Genetics and Molecular Medicine
Hyderabad-500004, India
Tel: 91-40-23210251
E-mail: [email protected]

Received date: December 02, 2015; Accepted date: March 07, 2016; Published date: March 14, 2016

Citation: Munshi A, Mohan V, Ahuja YR (2016) Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation. J Pharmacogenomics Pharmacoproteomics 7:156. doi: 10.4172/2153-0645.1000156

Copyright: © 2016 Munshi A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

It has been estimated that less than two percent of the mammalian genome encodes proteins, rest of the genome which was earlier considered as junk DNA is the treasure trove of non-coding RNAs (ncRNAs). Many ncRNAs have now been characterized. They constitute one of the largest families of gene regulators that are found in plants and animals. They form a complex network and have key roles in diverse regulatory pathways involved in human health and disease. In this review, different types of ncRNAs, their biogenesis, structure, function and evolutionary significance is showcased

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