alexa NON-ENZYMATIC ANTIOXIDANTS LEVELS IN HYPERTENSIVE, CANC


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Research Article

NON-ENZYMATIC ANTIOXIDANTS LEVELS IN HYPERTENSIVE, CANCER, TUBERCULOSIS AND HIV PATIENTS

1 Nnamah, N.K, 2Igboh, N. M; 2Onwubiko, D., 2Chigbu, L.N. 3Agomuo, E.N., 4Onyesom, C.A,5 Maduagwuna ,C.A,6 Iheanacho,K,M.E., 2Emuchey,C.I
  1. Department of chemical pathology, College of Medicine and Health Sciences, Nnamdi Azikiwe University Teaching Hospital, Nnewi. Nigeria
  2. College of Medicine and Health Sciences, Abia State University Uturu. Nigeria
  3. Department of Biochemistry, Faculty of Sciences. Imo State University, Owerri, Nigeria
  4. Department of Medical Biochemistry Delta State University, Abraka, Nigeria
  5. Department of Pharmacology, College of Medicine and Health Sciences, Abia State University Uturu. Nigeria
  6. Department of Biochemistry, Faculty of Sciences. Federal University of Technology Owerri, Nigeria
Received: 30 March 2013 Accepted: 16 April 2013
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Abstract

This study was carried out on 300 subjects to ascertain the levels of non-enzymatic antioxidants (vitamin C, reduced glutathione and uric acid levels) in hypertensive, cancer, tuberculosis and HIV patients. Study group comprises of sixty subjects from each group and sixty healthy subjects also served as control. The nonenzymatic antioxidants monitored were vitamin C, reduced glutathione and uric acid levels. The biochemical parameters were measured with standard methods. A Student t test was applied to assess the statistical difference of the above biological parameters between diseased patients and control group. We observed a very low level of vitamin C in cancer patient and the patients with HIV infection when compared to control group (P<0.05). Similarly, a significant reduction of serum reduced glutathione particularly in cancer and HIV patients when compared to control group was also observed. (P<0.05). Hyperuricemia was also observed in patients with cancer cells and those with HIV. We have observed very low levels of non enzymatic Antioxidants, thus creating oxidative stress, which might be playing an important role in progression of these diseases.

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