alexa Non-Functional P2X<sub>7</sub>: A Novel and Ubiquitous Target in Human Cancer | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Non-Functional P2X7: A Novel and Ubiquitous Target in Human Cancer

Julian A. Barden1*, Aysen Yuksel1, John Pedersen2, Suzanne Danieletto3 and Warick Delprado4
1Biosceptre International Ltd, Riverside Life Sciences, 11 Julius Ave, North Ryde, N.S.W. 2113, Australia
2TissuPath, 96B Ricketts Road, Mt Waverley Vic 3149, Australia
3SAN Pathology Department, 185 Fox Valley Rd, Wahroonga, N.S.W 2076, Australia
4Douglass Hanly Moir Pathology, 14 Giffnock Ave., Macquarie Park, N.S.W. 2113, Australia
Corresponding Author : Dr. Julian A. Barden
Director of Research, Biosceptre International Ltd
11 Julius Ave, North Ryde NSW 2113 Australia
Tel: +61 2 9490 8280, +61 4 1999 8918
Fax: +61 2 9490 5038
E-mail: [email protected]
Received June 05, 2014; Accepted July 11, 2014; Published July 18, 2014
Citation: Barden JA, Yuksel A, Pedersen J, Danieletto S, Delprado W (2014) Non-Functional P2X7: A Novel and Ubiquitous Target in Human Cancer. J Clin Cell Immunol 5:237. doi: 10.4172/2155-9899.1000237
Copyright: © 2014 Barden JA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The World Health Organisation reports there were 14.1 million new cancer cases and 8.2 million cancer deaths in 2012 demonstrating significant unmet medical needs exist. Modifications to cell death mechanisms that take place during cancer and the significant proliferative and metastatic potential of cancer cells have focused medical research onto targets and pathways that are known to control these critical functions. One such target is the P2X7 receptor. P2X7 is a purinergic receptor that forms ATP-gated channels ultimately mediating proliferation or cell death, depending on activation conditions. Recent preclinical studies have investigated the possibility that modulators of the P2X7 channel may provide innovative cancer therapeutic approaches. The P2X7 receptors expressed on cancer cells are found in a non-functional conformation we define as nfP2X7. The nfP2X7 receptor is unable to form the large pore conformation of the channel that is associated with driving cell death. In the present study we utilise antibodies that are specific to the nfP2X7 form of P2X7 to confirm the expression of nfP2X7 receptor in a panel of human cancer tissues. We demonstrate that the nfP2X7 is expressed ubiquitously on the surface of cancer cells and thus has potential to provide a novel and broad therapeutic cancer target.

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