Non-Negative Matrix Factorization Based Input Function Extraction for Mouse Imaging in Small Animal PET - Comparison with Arterial Blood Sampling and Factor Analysis
- *Corresponding Author:
- Ralph A. Bundschuh
Nuklearmedizinische Klinik und Poliklinik,
Klinikum rechts der Isar, der Technischen Universität München,
Ismaninger Str. 22, 81675 Munich, Germany
Tel: +49 - 89 - 4140 4570
Fax: +49 - 0 89 - 4140 4938
E-mail: [email protected]
Received date: November 22, 2012; Accepted date: April 21, 2012; Published date: April 27, 2012
Citation: Schulz D, Tapfer A, Buck A , Reeder S, Miederer M, et al.(2012) Non-Negative Matrix Factorization Based Input Function Extraction for Mouse Imaging in Small Animal PET - Comparison with Arterial Blood Sampling and Factor Analysis. J Mol Imaging Dynam 2:108. doi:10.4172/2155-9937.1000108
Copyright: © 2012 Schulz D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Retrieving the accurate time-tracer activity concentration curve of the blood (arterial input function)is mandatory for performing bio kinetic model analysis of dynamic PET data. Especially in small rodents, gathering the input function remains an active area of research as no generally applicable solution was found so far.