alexa Non-Negative Matrix Factorization Based Input Function Extraction for Mouse Imaging in Small Animal PET - Comparison with Arterial Blood Sampling and Factor Analysis | Abstract
ISSN: 2155-9937

Journal of Molecular Imaging & Dynamics
Open Access

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Research Article

Non-Negative Matrix Factorization Based Input Function Extraction for Mouse Imaging in Small Animal PET - Comparison with Arterial Blood Sampling and Factor Analysis

Dominik Schulz1#, Arne Tapfer2#, Andreas Buck1,4, Sybille Reeder1, Matthias Miederer3, Eliane Weidl1, Sibylle I. Ziegler1, Markus Schwaiger1 and Ralph A. Bundschuh*1,4

1Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany

2Department of Physics, TU München, Munich, Germany

3Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, Mainz, Germany

4Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Würzburg, Wuerzburg, Germany

#Co first authors

*Corresponding Author:
Ralph A. Bundschuh
Nuklearmedizinische Klinik und Poliklinik,
Klinikum rechts der Isar, der Technischen Universität München,
Ismaninger Str. 22, 81675 Munich, Germany
Tel: +49 - 89 - 4140 4570
Fax: +49 - 0 89 - 4140 4938
E-mail: [email protected]

Received date: November 22, 2012; Accepted date: April 21, 2012; Published date: April 27, 2012

Citation: Schulz D, Tapfer A, Buck A , Reeder S, Miederer M, et al.(2012) Non-Negative Matrix Factorization Based Input Function Extraction for Mouse Imaging in Small Animal PET - Comparison with Arterial Blood Sampling and Factor Analysis. J Mol Imaging Dynam 2:108. doi:10.4172/2155-9937.1000108

Copyright: © 2012 Schulz D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Retrieving the accurate time-tracer activity concentration curve of the blood (arterial input function)is mandatory for performing bio kinetic model analysis of dynamic PET data. Especially in small rodents, gathering the input function remains an active area of research as no generally applicable solution was found so far.

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