alexa Non-Secretory Multiple Myeloma with Lytic Bone Lesions about a New Observation | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Case Report

Non-Secretory Multiple Myeloma with Lytic Bone Lesions about a New Observation

Mounira El Euch, Fatma Ismail Ben Fredj*, Amel Rezgui, Monia Karmani, Fatma Derbeli, Raja Amri and Chedia Laouani Kechrid
Department of Internal Medicine, Sahloul Hospital, Sousse, Tunisia
Corresponding Author : Dr. Fatma Ben Fredj Ismail
Department of Internal Medicine
Sahloul Hospital, Sousse, Tunisia
Tel: 21698504387
E-mail: [email protected]
Received: April 04, 2011; Accepted: May 17, 2012; Published: May 23, 2012
Citation: El Euch M, Ben Fredj FI, Rezgui A, Karmani M, Derbeli F, et al. (2012) Non-Secretory Multiple Myeloma with Lytic Bone Lesions about a New Observation. J Clin Cell Immunol 3:120. doi:10.4172/2155-9899.1000120
Copyright: © 2012 El Euch M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Non-excretory myeloma is a rare variety of multiple myeloma in which classical techniques of research of the stigmata of chronic secretion fail to highlight the monoclonal peak or proteinuria of Bence Jones. Lytic bone lesions are rare in this type of myeloma. We report the case of a patient in whom we confirmed multiple myeloma by bone marrow aspiration and we have classified stage III of Durie and Salmon in view of hypercalcemia, anemia, and lytic lesions observed. However, we could not isolate a secretion of monoclonal immunoglobulin in blood but urinary secretion was evident by proteinuria and urinary light chains. The radiographs of our patient were highly suggestive of osteolysis seen diffuse the practice of sternal puncture has emerged even in the absence of criteria such as blood secretion highlighting the monoclonal peak in serum protein electrophoresis or the quantitation of immunoglobulins. Our case original seen that the diffuse osteolytic lesions were often observed within the secretory disease and rarely in the form of non-secreting.

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