Normal Response of Active GLP-1 Level like Substances to Test Meal in Non-Obese Type 2 Diabetic Japanese Patients with Complications and Receiving TreatmentsKyuzi Kamoi1,4*, Nobumasa Ohara2,3, Ikarashi Tomoo2,3,5, You Shinozaki1,2, Kazuo Furukawa1,2 and Hideo Sasaki3
- *Corresponding Author:
- Kyuzi Kamoi, MD, M.Sc.
Department of Health and Nutrition
University of Niigata Prefecture, 471, Ebigase
Higashi-ku, Niigata, Niigata 950-8680, Japan
Tel: +81 025-270-1300
Fax: +81 025-270-5173
E-mail: [email protected]
Received date September 08, 2011; Accepted date October 15, 2011; Published date October 20, 2011
Citation: Kamoi K, Ohara N, Tomoo I, Shinozaki Y, Furukawa K (2011) Normal Response of Active GLP-1 like Substances Level to Test Meal in Non-Obese Type 2 Diabetic Japanese Patients with Complications and Receiving Treatments. J Diabetes Metab 2:147. doi:10.4172/2155-6156.1000147
Copyright: © 2011 Kamoi K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Study has shown no significant differences in basal and postprandial plasma active glucagon-like peptide-1 (p-active GLP-1) levels following test meal (TM) between complication- and treatment-naïve non-obese Japanese patients with type 2 diabetes (T2DM) and controls.
Methods: In non-obese Japanese patients with T2DM (n=23, group 1) and healthy individuals as control (n=13, group 2), blood levels of plasma glucose (PG), serum insulin (s-IRI), serum C-peptide (s-CPR) and p-active GLP-1 like substances (p-active GLP-1-S) were measured 0, 30, and 60 min after TM (520-560 kcal. 23% fat, 60% carbohydrate and 17% protein). HbA1c levels were also measured in the groups. Patients with mean of 9.2 years disease had various complications and treatment with diet, exercise and/or oral medical drugs except incretin-related drugs for hyperglycemia.
Results: There was no significant difference in mean of sex, age, or BMI between groups. Means of HbA1c and basal and postprandial PG with area under curve (AUC), and HOMA-R were significantly higher in group 1 than in group 2. Means of HOMA-β and insulinogenic index after ingestion of TM were significantly lower in group 1 than in group 2. However, there were no significant differences in means of basal and postprandial with AUC levels of s-IRI, s-CPR and p-active GLP-1-S levels between groups.
Conclusion: These results indicated that a response of p-active GLP-1-S to TM in non-obese Japanese patients with T2DM associated with a long duration of disease, various complications and various treatments with except incretin-related drugs was similar to those in non-obese healthy individuals.