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ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Review Article

Not Only Diabetic Retinopathy - Retinal Vascular Lesions and Signs in Diabetic Patients: Description and Associations

Janne P. Kytö1,2*, Maritta Lindström-Karjalainen1,3 and Paula A. Summanen1,4

1Department of Ophthalmology, Helsinki University Central Hospital, Finland

2Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Finland

3Department of Oncology, Helsinki University Central Hospital, Finland

4Photographic Screening Unit, Herttoniemi Hospital, City of Helsinki, Finland

*Corresponding Author:
Janne Kytö, MD
Department of Ophthalmology
Helsinki University Central Hospital
P.O. Box 220, FI-00029 HUS, Helsinki, Finland
Tel: +358505810384
E-mail: [email protected]

Received date November 23, 2011; Accepted date January 15, 2012; Published date January 20, 2012

Citation: Kytö JP, Lindström-Karjalainen M, Summanen PA (2012) Not Only Diabetic Retinopathy - Retinal Vascular Lesions and Signs in Diabetic Patients: Description and Associations. J Diabetes Metab S3:003. doi:10.4172/2155-6156.S3-003

Copyright: © 2012 Kytö JP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Retinal vascular changes other than diabetic retinopathy (DRP) namely microaneurysms, intraretinal microvascular abnormalities so called IRMA, microinfarctions, hemorrhages, lipid exudates and edema, as well as venous beading and new vessels (NV) on the disk and/or on the retina and their sequalae pre-retinal and vitreous hemorrhages and fibrovascular proliferations and vitreoretinal tractions are common in diabetic patients. These changes are general or focal arteriolar narrowing or arteriolar or venous dilatation, arteriolar sinusoidal elongation or straightening, venous tortuosity, increased arteriolar wall reflex and arterio-venous crossing signs. They reflect cumulative response to aging, cardiovascular risk factors such as hyperglycemia, hypertension and dyslipidemia, as well as inflammation and endothelial dysfunction. Retinal vascular changes are under the influence of both systemic and environmental as well as genetic factors and serve as cardiovascular risk stratification indicator. Furthermore, these changes may cause as such ocular morbidity and threaten vision and influence the occurrence and progression of DRP. Many of these changes were recognized soon after the invention of ophthalmoscope by von Helmholz in 1851 and have since been described in literature. Many of these changes can be accurately measured today.

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