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ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Research Article

NOV-002, A Glutathione Disulfide Mimetic, Suppresses Tumor Cell Invasion and Metastasis

Kiranmai Gumireddy1#, Anping Li1#, Lili Cao1,2, Jinchun Yan3, Lin Liu1,4, Xiaowei Xu5, Christopher Pazoles6 and Qihong Huang1*

1The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA

2Central labortary, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P. R. China

3University of Washington Medical Center, 1959 N.E. Pacific Street, Seattle, WA 98195, USA

4Department of Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P. R. China

5Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA

6Novelos Therapeutics Inc. One Gateway Center, Newton, MA 02458, USA

#These authors contributed equally to this study

*Corresponding Author:
Qihong Huang
The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104, USA
E-mail: mailto:[email protected]

Received date: March 04, 2013; Accepted date: April 26, 2013; Published date: April 30, 2013

Citation: Gumireddy K, Li A, Cao L, Yan J, Liu L, et al. (2013) NOV-002, A Glutathione Disulfide Mimetic, Suppresses Tumor Cell Invasion and Metastasis. J Carcinogene Mutagene S7:002. doi: 10.4172/2157-2518.S7-002

Copyright: © 2013 Gumireddy K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Metastasis is the major cause of death in cancer. Most therapies currently in the clinic aim to eradicate primary tumor, but do not have ideal effects on metastasis. The lack of effective therapy in metastasis prevention and treatment results in high mortality rate in cancer patients with advanced diseases. Here we report the oxidized glutathione small molecule compound NOV-002 reduces cancer cell invasion in vitro and metastasis in an animal model in combination with chemotherapy drug gemcitabine. NOV-002 regulates cell signaling pathways by suppressing ErbB2 and PI3K phosphorylation and subsequent inhibition of Akt and RhoA activation. Our results suggest that NOV-002 affects cell signaling pathways that are critical for invasion and metastasis and can potentially be effective in metastasis treatment in combination of other chemotherapies.

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