alexa NOVEL APPROACH FOR NOSE-TO-BRAIN DRUG DELIVERY BYPASSING BLOOD BRAIN BARRIER BY PRESSURIZED OLFACTORY DELIVERY DEVICE | OMICS International | Abstract
ISSN: 1920-4159

Journal of Applied Pharmacy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

NOVEL APPROACH FOR NOSE-TO-BRAIN DRUG DELIVERY BYPASSING BLOOD BRAIN BARRIER BY PRESSURIZED OLFACTORY DELIVERY DEVICE

Abstract

Although there is presence of a dense network of the cerebral vasculature, systemic delivery of therapeutics to the central nervous system (CNS) is infective for greater than 98% of small molecules and for nearly 100% of large molecules. This is imputable to the presence of the blood brain barrier (BBB), which prevents most foreign substances, even many beneficial therapeutics, from getting into the psyche from the systemic circulation. Certain small molecules, peptide, and protein therapeutics given systematically reach the brain parenchyma by crossing BBB but high systemic doses are required to reach a therapeutic level that contributes to adverse effects in the physical structure. The BBB is a system of layers of cells at the cerebral capillary endothelium, the choroid plexus epithelium, and the arachnoid membranes, which are linked by tight junctions (zonulae occludens) and which together separate the mind and the cerebro-spinal fluid (CSF) from the line. These tight endothelial junctions can be 100 times tighter than junctions of other capillary endothelium. Therefore, the barrier has many attributes similar to a continuous cell membrane, allowing lipid soluble molecule transport across the membrane where hydrophilic solutes demonstrate minimal permeation. Different strategies have been developed to cross the BBB have been involved, such as synthesis of small molecules to exploit existing Carrier-Mediated Transport (CMT) or re-engineering large molecules with molecular ‘Trojan horse’ delivery systems. These approaches may allow transport via Receptor-Mediated Transfer (RMT) systems in the BBB. An alternative approach is targeted intranasal delivery, which is potentially applicable which covers broader area of molecules, where the goal is to circumvent, rather than cross, the BBB.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7