alexa Novel Avian Flu A (H7N9): Clinical and Epidemiological Aspects, and Management
ISSN: 2161-0517

Virology & Mycology
Open Access

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Review Article

Novel Avian Flu A (H7N9): Clinical and Epidemiological Aspects, and Management

Attapon Cheepsattayakorn 1* and Ruangrong Cheepsattayakorn2

110th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand, 10th Office of Disease Prevention and Control, Chiang Mai, Department of Disease Control, Ministry of Public Health, Thailand

2Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author:
Attapon Cheepsattayakorn, MD, FRCP
FRCP(Edin), FRCP(Glasg), FACP, FCCP, FRCP (Thai)
10th Zonal Tuberculosis and Chest Disease Center
143 Sridornchai Road Changklan Muang Chiang Mai 50100 Thailand
Tel: 66-53-140767, 66-53-276364
Fax: 66-53-140773, 66-53-273590
E-mail: [email protected]

Received date: August 02, 2013; Accepted date: September 17, 2013; Published date: September 20, 2013

Citation: Cheepsattayakorn A, Cheepsattayakorn R (2013) Novel Avian Flu A (H7N9): Clinical and Epidemiological Aspects, and Management. Virol Mycol 2:121. doi:10.4172/2161-0517.1000121

Copyright: © 2013 Cheepsattayakorn A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Avian influenza A (H7N9) virus, the latest avian influenza virus strain was once considered a relatively rare cause of infection and low pathogenic. This novel virus spreading among three cases was firstly reported on 31 March 2013 in eastern China. By 31 March 2013, the number of laboratory-confirmed influenza H7N9 virus infections reached 132, with 37 deaths. There are age and gender differences between H7N9 virus-infected and H5N1 virus-infected patients. Currently, the reservoir or source of this novel virus is unknown but is most likely to be live-bird markets in eastern China. Low pathogenicity in poultry and birds and no evidence of human-to-human transmission have been noted. The incubation period of this novel virus ranges 3 to 8 days, thus the most appropriate time for contacts observation and treatment is 10 full days. The best diagnostic method for confirmation of H7N9 virus infections is real-time reversetranscriptase polymerase chain reaction. Lymphopenia and thrombocytopenia can be predictors of acute respiratory distress syndrome and death. Approximately, 20% of cases without appropriate treatment with antivirals are dead with respiratory failure and multiple organ failure. Fortunately, Oseltamivir and Zanamivir are still susceptible to this novel virus. Currently, no specific vaccines against H7N9 viruses are available. China scenario and its model against spreading of this virus can be an effective model for other countries for protection of this virus spreading.

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