alexa Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging

Kien Voon Kong1#, Lun-De Liao2#, Douglas Goh1, Nitish V Thakor2,3* and Malini Olivo1,4*

1Singapore Bioimaging Consortium, Agency for Science, Technology, and Research (A*STAR), 11 Biopolis Way, #02-02 Helios, Singapore 138667, Singapore

2Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, #05-COR, Singapore 117456, Singapore

3Department of Biomedical Engineering, Johns Hopkins University, Traylor 701/720 Rutland Ave, Baltimore, 21205, USA

4School of Physics, National University of Ireland, University Road, Galway, Ireland

#These authors contributed equally to this work

*Corresponding Author:
Malini Olivo
Singapore Bioimaging Consortium
Agency for Science, Technology and Research (A*STAR)
11 Biopolis Way, #02-02 Helios
Singapore 138667, Singapor
Tel: (65)64788752
Fax: (65)64789957
E-mail: [email protected]

Nitish V Thakor
Singapore Institute for Neurotechnology (SINAPSE)
National University of Singapore
28 Medical Drive, #05-COR, Singapore 117456, Singapore
E-mail: [email protected]

Received Date: July 31, 2014; Accepted Date: August 27, 2014; Published Date: August 30, 2014

Citation: Kong KV, Liao LD, Goh D, Thakor NV, Olivo M (2014) Novel Biodegradable Polymer Tethered Platinum (II) for Photoacoustic Imaging. J Nanomed Nanotechnol 5:223. doi:10.4172/2157-7439.1000223

Copyright: © 2014 Kong KV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Photoacoustic microscopy (PAM) is an emerging imaging diagnostic technique for various diseases. Coupled with contrast agents, photoacoustic (PA) imaging yields additional information to facilitate an accurate diagnosis. While many organic-based contrast agents, notably those of cyanine dyes, nanoparticles, polyhydroxy-fullerene and carbon nanotubes, have become available, the use of transition metal as contrast agent is scant. Here, for the first time, we report a platinum II-based biodegradable polymer for PA imaging that is capable of effective cellular internalization with very low cytotoxicity. The experiment results show great promise as a novel photoacoustic contrast agent as its detectable PA signal was observed both in cell imaging and in vivo rat cerebral vascular imaging via designed PAM. This work exemplifies the incorporation of transition metal complex with polymeric nanoparticles, further expanding the field of the ability of PA imaging.

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