alexa Novel Coated Wires Sensors with Flow-Injection for Potentiometric Determination of Neostigmine in Bulk, Amostigmine and Human Urine | OMICS International | Abstract
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
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Research Article

Novel Coated Wires Sensors with Flow-Injection for Potentiometric Determination of Neostigmine in Bulk, Amostigmine and Human Urine

Khorshid AF1* and Issa YM2

1Pharmaceutical Analytical Chemistry department, Faculty of Pharmacy, Nahda University, NUB, New Beni-Sueff, Egypt

2Chemistry Department, Faculty of Science, Cairo University, Egypt

*Corresponding Author:
Khorshid AF
Pharmaceutical Analytical Chemistry department
Faculty of Pharmacy, Nahda University
NUB, New Beni-Sueff, Egypt
Tel: +2082-2284680
E-mail: [email protected]

Received Date: March 20, 2015; Accepted April 13, 2015; Published Date: April 27, 2015

Citation: Khorshid AF, Issa YM (2015) Novel Coated Wires Sensors with Flow- Injection for Potentiometric Determination of Neostigmine in Bulk, Amostigmine and Human Urine. J Bioequiv Availab 7:131-139. doi: 10.4172/jbb.1000227

Copyright: © 2015 Khorshid AF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Four types of coated wires sensors (silver, copper, graphite and glassy carbon) are constructed for the determination of neostigmine (Ns) based on the ion-pair associates neostigmine silicotungstate (Ns-ST), neostigmine silicomolybdate (Ns-SM), neostigmine phosphotungstate (Ns-PT), neostigmine phospho molybdate (Ns-PM),and ion-pairs neostigmine tetraphenylborate (Ns-TPB) in a poly (vinyl chloride) as coated film with a plasticized tricresylphthalate (TCP). The four types sensors are showed a Nernstain slopes ranged from 59-64 mV per decade in batch and 65-70 mV per decade in flow injection conditions (FIA) over a neostigmine concentration ranged from 5.0x10-7-1.0x10-2 M and within the pH range 4.0-11.0. The influences of coated film composition, pH of the Ns and foreign ions on the sensors performance were investigated and were found to be very selective, precise and excellent selectivity. The sensors were successfully applied to the potentiometric determination of neostigmine bromide in pure state, in amostigmine, and human urine. FI analysis and dissolution profile for determination neostigmine were investigated. The data were comparable with official methods for the assay and excellent percentage recovery was obtained.

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