Novel Drug Delivery Systems to Improve Bioavailability of Curcumin
Asish K Dutta* and Elizabeth Ikiki
Notre Dame of Maryland University, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD 21210, USA
- *Corresponding Author:
- Asish K Dutta
Department of Pharmaceutical Sciences
School of Pharmacy
Notre Dame of Maryland University
4701 North Charles Street
Baltimore, MD 21210, USA
E-mail: [email protected]; [email protected]
Received Date: November 23, 2013; Accepted Date: December 22, 2013; Published Date: December 30, 2013
Citation: Dutta AK, Ikiki E (2013) Novel Drug Delivery Systems to Improve Bioavailability of Curcumin. J Bioequiv Availab 6: 001-009. doi: 10.4172/jbb.1000172
Copyright: © 2013 Dutta AK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Curcumin, the major component of common food spice, turmeric, is a potential compound for the treatment and prevention of a wide variety of human diseases and has wide spectrum of biological and pharmacological activities. Various studies have proven the safety and efficacy of curcumin at very high doses; however the relative bioavailability of curcumin is of major concern. It has extremely low aqueous solubility and it is still unclear if it metabolizes into active or inactive metabolites. In this review, we have discussed the various novel drug delivery systems of curcumin such as various nanoparticles, micellar formulations, liposomes and cyclodextrin inclusion complexes that have been reported in order to improve the solubility, bioavailability and efficacy of curcumin.