Journal of Blood Disorders & Transfusion

Abstract

Novel Functions of Therapeutic Platelets as “Immune Cells”

Olivier Garraud, Patricia Chavarin, Patrick Fabrigli, Hind Hamzeh-Cognasse and Fabrice Cognasse

Platelet components are commonly transfused to bleeding in patients in the absence of a suitable alternative. If one exempts granulocyte concentrates, this labile blood component is associated with the most common infectious and immune-related hazards. Though infection can be prevented, immune-related reactions are more difficult to combat because the physiopathology is not fully understood. Recent research has placed platelets in the immune continuum as cells fully licensed for innate immunity and inflammation, possibly bridging innate and adaptive immunity. This novel paradigm provides clues for understanding how platelets can mediate immunerelated side effects when transfused to a patient in need, and to address prevention strategies. The present paper discusses novel functions associated with platelets and their potential response upon encounters with a recipient’s cells during transfusion.