alexa Novel Methodology and Process Optimization for the Synthesis of Flavones


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Research Article

Novel Methodology and Process Optimization for the Synthesis of Flavones

 
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Abstract

Flavones are medicinal natural products. Prevention and cure of disease using flavonoids as a phytochemicals are known. Due to its wide spectrum activities it attracts researchers of the world. Hence cheap easy lab feasible synthetic methodology is demand of pharmaceutical industries. In that point of view we optimized Claisen-Schmidt method for the synthesis of flavones. Different molar ratios, solvent, temperature and catalysts are examined during experiments. Also effect of structure and substituent on the product formation is notified. Effect of groups like hydroxyl, methoxy and other on starting material (i. e. 2-hydroxy acetophenone and aromatic aldehyde) was studied. Attention is given for the synthesis of basic flavone molecules which are pharmaceutically active and whose skeletal modification gives new lead molecules. Hydroxyl group is important on flavone molecule for its versatile biological activities. So alternate method for the synthesis of flavone is methylation of starting material or methylated starting material must be used. After comparison of hydroxylated starting material and menthoxylated starting material we found that later is easy to synthesize flavones

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