alexa Novel Nuclear Biology of Small Non-Coding RNAs
ISSN: 2329-6682

Gene Technology
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Short Communication

Novel Nuclear Biology of Small Non-Coding RNAs

Ida-Liisa Kolari1#, Pia Laitinen1#, Mikko P. Turunen1 and Seppo Ylä-Herttuala1,2*
1Department of Biotechnology and Molecular Medicine, A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland
2Science Service Center and Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland
#Authors with equal contribution
Corresponding Author : Seppo Ylä-Herttuala
A. I. Virtanen Institute for Molecular Sciences
University of Eastern Finland
P.O. Box 1627, FIN-70211 Kuopio
Finland
Tel: +358 40 355 2075
Fax: +358 17 163751
E-mail: [email protected]
Received: March 03, 2015; Accepted: April 01, 2015; Published: April 06, 2015
Citation: Kolari IL, Laitinen P, Turunen MP, Ylä-Herttuala S (2015) Novel Nuclear Biology of Small Non-Coding RNAs. Gene Technol 4:120. doi:10.4172/2329-6682.1000120
Copyright: © 2015 Kolari IL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

When ENCODE project was recently published it became evident that there is unexpectedly large amount of non-coding RNAs (ncRNAs) in mammalian cells and these findings have boosted a wide interest in the role of ncRNAs in both basic cellular processes and their functions in pathological conditions. The first big boom in ncRNA research was fueled by findings of Fire and Mello after they had found RNA interference (RNAi), which discovery was awarded Nobel prize in 2006. Small interfering RNAs (siRNA) and microRNAs (miRNAs) have since been developed both as important tools for molecular biology research and also as therapeutics for gene therapy applications. These ncRNAs have been thought to function mostly in cytoplasm of target cells mediating post transcriptional gene silencing (PTGS). However, Morris et al.

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