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ISSN: 2167-0501

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Research Article

Novel Targeted Therapy for Advanced Gastric Cancer

Hui-yan Luo1,2 and Rui-hua Xu1*
1Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, People’s Republic of China
2Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510006, People’s Republic of China
Corresponding Author : Rui-hua Xu, M.D. Ph.D
Department of Medical Oncology, Sun Yat-Sen University Cancer Center
651 Dong Feng Road East, Guangzhou 510060
People’s Republic of China
Tel: 86-13719459226
Fax: (011)86-20-87343468
E-mail: [email protected]
Received October 29, 2014; Accepted December 06, 2014; Published December 12, 2014
Citation: Xu Rh, Luo Hy (2014) Novel Targeted Therapy for Advanced Gastric Cancer. Biochem Pharmacol (Los Angel) 4:154. doi:10.4172/2167-0501.1000154
Copyright: © 2014 Xu Rh, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Despite its decreasing incidence in western countries, the care of gastric cancer remains a concern. As gastric cancer is often diagnosed at an advanced stage, the prognosis of patients with advanced disease remains dismal. Recent trials in advanced gastric cancer have been focused on targeted therapies. Agents targeting EGFR1 and HER2 have been widely tested. The addition of trastuzumab to cisplatin/fluoropyrimidine-based combination chemotherapy significantly improved survival in patients with HER2 positive advanced gastric cancer, which is now the new standard of care by recent ToGA trial. Other agents targeting VEGF, the PI3K–Akt–mTOR pathway, and other biological pathways have also been investigated in clinical trials, but showed little impact on the survival of patients. This review will focus on the recent progress in targeted agents for the treatment of AGC and summarize the current clinical evidence and ongoing trials supporting the use of targeted agents in the treatment of patients with AGC.

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