alexa Novel Thienopyrimidine Derivatives Containing 1,2,4-tri
ISSN: 2161-0444

Medicinal chemistry
Open Access

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Research Article

Novel Thienopyrimidine Derivatives Containing 1,2,4-triazoles and 1,3,4-oxadiazoles as Potent Antimicrobial Activity

Nagaraju Kerru, Triloknadh Settypalli, Harikrishana Nallapaneni and Venkata Rao Chunduri*

Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India

*Corresponding Author:
Venkata Rao Chunduri
Department of Chemistry, Sri Venkateswara University
Tirupati 517502, Andhra Pradesh, India
Tel: +91-877-2289303
Fax: +91-877-2249532
E-mail: [email protected]

Received date: July 31, 2014; Accepted date: August 27, 2014; Published date: August 30, 2014

Citation: Kerru N, Settypalli T, Nallapaneni H, Chunduri VR (2014) Novel Thienopyrimidine Derivatives Containing 1,2,4-triazoles and 1,3,4-oxadiazoles as Potent Antimicrobial Activity. Med chem 4:623-629. doi:10.4172/2161-0444.1000204

Copyright: © 2014 Kerru N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A series of thienopyrimidine oxadiazolederivatives (5a-l) were synthesized by cyclic condensation of substituted aroylhydrazides with triazole of carboxylic acid (4a-c). The synthesized compounds were characterized on the basis of their spectral (IR, 1H and 13C NMR) data and screened for antimicrobial activity where compounds 5b and 5d showed significant activity.

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