Novel Upconversion Fluorescent Probe for Schistosoma japonicum Cercariae Imaging
- *Corresponding Author:
- Yibao Li
Key Laboratory of Organo-pharmaceutical Chemistr
Gannan Normal University, Ganzhou 341000, PR China
Tel/Fax: +86 (0)797 8393536
E-mail: [email protected]; [email protected]
Received date: May 19, 2015; Accepted date: June 10, 2015; Published date: June 14, 2015
Citation: Fan Y, Xie Y, Chen L, Liu W, Li X, et al. (2015) Novel Upconversion Fluorescent Probe for Schistosoma japonicum Cercariae Imaging. Med chem 5:231-234. doi:10.4172/2161-0444.1000269
Copyright: © 2015 Fan Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Schistosomiasis has influence on people’s security and daily life significantly, while cercarial stage of the schistosome life-cycle is the only infectious period. To detect cercarial efficiently, we synthesized rare-earth upconversion nanophosphors UCs-Ni loaded with niclosamide. The fluorescenceof UCs-Ni was demonstrated by the fluorescence emission spectra. The cell imaging test illustrated that UCs-Ni was biocompatible, cell-permeable and suitable for cercariae imaging. When it has been utilized for cercariae imaging, we found that the UCs-Ni could penetrate into cercariae.