alexa Novel Upconversion Fluorescent Probe for Schistosoma japonicum Cercariae Imaging | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Novel Upconversion Fluorescent Probe for Schistosoma japonicum Cercariae Imaging

Yulan Fan1, Yunzhi Xie1, Linxiu Chen1, Wei Liu1, Xun Li1, Yibao Li1* and Xiaolin Fan1,2

1Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, PR China

2Material and Chemical Engineering Department, Pingxiang University, Pingxiang 337055, China

*Corresponding Author:
Yibao Li
Key Laboratory of Organo-pharmaceutical Chemistr
Gannan Normal University, Ganzhou 341000, PR China
Tel/Fax: +86 (0)797 8393536
E-mail: [email protected]; [email protected]

Received date: May 19, 2015; Accepted date: June 10, 2015; Published date: June 14, 2015

Citation: Fan Y, Xie Y, Chen L, Liu W, Li X, et al. (2015) Novel Upconversion Fluorescent Probe for Schistosoma japonicum Cercariae Imaging. Med chem 5:231-234. doi:10.4172/2161-0444.1000269

Copyright: © 2015 Fan Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Schistosomiasis has influence on people’s security and daily life significantly, while cercarial stage of the schistosome life-cycle is the only infectious period. To detect cercarial efficiently, we synthesized rare-earth upconversion nanophosphors UCs-Ni loaded with niclosamide. The fluorescenceof UCs-Ni was demonstrated by the fluorescence emission spectra. The cell imaging test illustrated that UCs-Ni was biocompatible, cell-permeable and suitable for cercariae imaging. When it has been utilized for cercariae imaging, we found that the UCs-Ni could penetrate into cercariae.

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