alexa NSAIDs; Safety and Risk Assessment in CVS Events, Compa
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Review Article

NSAIDs; Safety and Risk Assessment in CVS Events, Comparisons and Facts

Hina Hasnain1, Huma Ali1, Anum Tariq1, Farya Zafar1 and Safila Naveed2*

1Ziauddin University, Karachi, Pakistan

2Jinnah University for Women, Karachi, Pakistan

*Corresponding Author:
Safila Naveed
Faculty of Pharmacy, Jinnah University for Women
Karachi, Pakistan
Tel: 0092-03002621917
E-mail: [email protected]

Received Date: November 25, 2015 Accepted Date: January 27, 2016 Published Date: February 04, 2016

Citation: Hasnain H, Ali H, Tariq A, Zafar F, Naveed S (2016) NSAIDs; Safety and Risk Assessment in CVS Events, Comparisons and Facts. J Bioequiv Availab 8:084-088. doi:10.4172/jbb.1000273

Copyright: © 2016 Hasnain H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Products of Non-steroidal anti-inflammatory drugs (NSAIDs) are principally and most widely utilized due to their multipurpose actions, i.e., analgesic anti pyretic and anti-inflammatory effect. Beside their therapeutic effect their toxic effect based on their selectivity of cyclooxygenase (COX) enzyme. While cardiovascular toxicities associated with NSAIDs are mainly related with COX-2 selective inhibitor and primarily dependent on their dose time and duration. Variability in therapeutic response and susceptibility to toxicity is well recognized and can be manageable if considerable precautions implement.

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