Reach Us +1-947-333-4405
Nuclear Receptor Control of Myeloid Cell Responses - Implications for CNS Autoimmunity | OMICS International | Abstract
ISSN: 2161-1149

Rheumatology: Current Research
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Nuclear Receptor Control of Myeloid Cell Responses - Implications for CNS Autoimmunity

Stephanie Hucke1, Heinz Wiendl1, Percy Knolle2,3 and Luisa Klotz1*

1Department für Neurologie, Klinik für Allgemeine Neurologie, Universitätsklinikum Münster, Germany

2Institute für Molekulare Medizin und Experimentelle Immunologie, Universität Bonn, Germany

3Institut für Molekulare Medizin, Technische Universität München, Germany

*Corresponding Author:
Luisa Klotz
Department für Neurologie, Klinik für Allgemeine Neurologie
Universitätsklinikum Münster, Germany
E-mail: [email protected]

Received date: July 29, 2013; Accepted date: September 30, 2013; Published date: October 07, 2013

Citation: Hucke S, Wiendl H, Knolle P, Klotz L (2013) Nuclear Receptor Control of Myeloid Cell Responses - Implications for CNS Autoimmunity. Rheumatology 3:124. doi: 10.4172/2161-1149.1000124

Copyright: © 2013 Hucke S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


During autoimmunity of the central nervous system (CNS), such as Multiple Sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), myeloid cells play a central role in shaping the local inflammatory milieu and significantly contribute to the extent of disease pathology. Myeloid cells contribute to local reactivation of encephalitogenic T cells and, through production of pro-inflammatory mediators, also promote neurotoxicity and demyelination. In contrast, myeloid cells that acquired an anti-inflammatory phenotype ameliorate CNS autoimmunity and significantly contribute to resolution of inflammation. In this review we will discuss the role of selected nuclear receptors in modifying myeloid cell immune responses during autoimmune inflammation of the CNS and their potential as new targets for treatment regimens in MS.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2019-20
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

ankara escort

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

pendik escort

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2019 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version