alexa Numb Chin Syndrome in Multiple Myeloma Patients: A Harb
ISSN: 2471-8726

Oral Health Case Reports
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Case Report

Numb Chin Syndrome in Multiple Myeloma Patients: A Harbinger of Ominous Prognosis: Case Series and Review of Literature

Katz J1*, Singer C1, Kashtawari D2, Nair MK3 and Moreb JS3

1Division of Oral Medicine, Department of Oral and Maxillofacial Diagnostic Sciences, College of Dentistry, University of Florida, USA

2Division of Oral and Maxillofacial Radiology, Colleges of Dentistry and Medicine, University of Florida, USA

3Department of Medicine, College of Medicine, University of Florida, USA

*Corresponding Author:
Dr. Joseph Katz
Department of Oral Diagnostic Sciences
University of Florida College of Dentistry
S PO Box 100414, Gainesville FL 32606, USA
Tel: 352-273-6685
E-mail: [email protected]

Received date: December 30, 2015; Accepted date: January 04, 2016; Published date: January 14, 2016

Citation: Katz J, Singer C, Kashtawari D, Nair MK, Moreb JS (2016) Numb Chin Syndrome in Multiple Myeloma Patients: A Harbinger of Ominous Prognosis: Case Series and Review of Literature. Oral health case Rep 1:102. doi:10.4172/2471-8726.1000102

Copyright: © 2016 Katz J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Numb chin syndrome (NCS), or mental nerve neuropathy, is a sensory neuropathy of the mental nerve and is characterized by hypoesthesia, paresthesia, or a numbness sensation of the chin and lower lip. NCS is caused by multiple etiologies including cancer invasion. We present a case series of three multiple myeloma patients with NCS where the jaw symptoms are a manifestation of disease relapse with extra-medullary myeloma infiltration, including soft tissue plasmacytoma involving the mental nerve noted along the jaw bone. The soft tissue plasmacytoma was detected using magnetic resonance imaging (MRI), which is the preferable diagnostic imaging technique to evaluate this type of problem. Furthermore, we found that in all cases, the involved immunoglobulin was IgA. This is interesting because IgA is the main immunoglobulin secreted by salivary glands. In addition, it seems that NCS could serve as one of the ominous prognostic factors in these patients.


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