alexa Obesity and Diabetes Mellitus
ISSN: 2165-8048

Internal Medicine: Open Access
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Research Article

Obesity and Diabetes Mellitus

Kyuzi Kamoi1,2* and Hideo Sasaki3,4
1Department of Health and Nutrition, University of Niigata Prefecture, Niigata, Niigata 950-8680, Japan
2Department of Medicine, Ojiya General Hospital, Ojiya, Niigata 947-8601, Japan
3Emeritus Professors, Yamagata University Faculty of Medicine, Yamagata, Yamagata 990-9585, Japan
4Diabetes Clinic, Kuriyama Hospital, Yotukaido City, Chiba 286-0027, Japan
*Corresponding Author : Kyuzi Kamoi
Department of Health and Nutrition
University of Niigata Prefecture
Niigata, Niigata 950-8680, Japan
Tel: +81 0258-83-3600
Fax: +81 0258-82-8223
E-mail: [email protected]
Received February 09, 2014; Accepted March 28, 2014; Published April 06, 2014
Citation: Kamoi K, Sasaki H (2014) Obesity and Diabetes Mellitus. Intern Med S6:004. doi:10.4172/2165-8048.S6-004
Copyright: © 2014 Kamoi K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Backgrounds: Generally, a prevalence of obesity increasing constantly represents one of major health care and social problems. Many researchers indicate that obesity has a risk factor for type 2 diabetes mellitus (T2DM), but some persons believe that obesity may occur T2DM. GLP-1 and GIP as incretin hormone are secreted in response to ingestion of nutrients. In the circulation, they are rapidly inactivated by dipeptidyl peptidase-4. We report interesting findings on secretion of incretin after test meal (TM) in Japanese patients with type 1 diabetes mellitus (T1 DM) and T2DM associated with or without obesity.

Materials and Methods: In Japan, ≧ 25 kg/m2 in BMI are defined as obesity. After overnight fast, subjects were ingested of TM (550 kcal) comprised of 60% carbohydrate, 23% fat and 17% protein. Based on GLP-1, patients with T1DM (n=10) were treated with multiple daily injections of insulin (MDI) or CSII. Non-obese (n=23) and obese (n=24) patients with T2DM with micro- and macroangiopathy were treated with oral drugs for various disease. Based on GIP, patients with T1DM (n=15) and T2DM (n=29) were treated with MDI or CSII for T1DM and oral drugs for T2DM, respectively.

Results: Basal and postprandial levels of plasma active GLP-1 (p-GLP-1) after TM in Japanese patient with T1DM and T2DM are similar to those with control, but basal and postprandial ratio of p-GLP-1/glucose are low compared with controls. AUCs of plasma GIP at early-phase were significant negatively and positively related to BMI in patients with T1DM and T2DM, respectively.

Conclusions: Japanese patients with T2DM regards of obesity may have a low secretion of GLP-1, which may be due to genetic factors. However, there is no T2DM in obese persons without low secretion of GLP-1. Therefore, risk factors for DM are important to diagnose T2DM.


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