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Obesity Decreases Serum Selenium Levels in a Mammary Tumor Zucker Rat Model | OMICS International | Abstract
ISSN: 2376-1318

Vitamins & Minerals
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Research Article

Obesity Decreases Serum Selenium Levels in a Mammary Tumor Zucker Rat Model

Reza Hakkak1, 2, 3*
1Department of Dietetics and Nutrition, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA
2Arkansas Children Hospital Research Institute, 13 Children’s Way, Little Rock, AR 72202, USA
3Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72202, USA
Corresponding Author : Dr. Reza Hakkak
Department of Dietetics and Nutrition
4301 W. Markham St. Mail Slot 627
Little Rock, AR 72205, USA
E-mail: [email protected]
Received May 17, 2012; Accepted June 26, 2012; Published July 01, 2012
Citation: Hakkak R (2012) Obesity Decreases Serum Selenium Levels in a Mammary Tumor Zucker Rat Model. Vitam Trace Elem 1:106. doi:10.4172/2167-0390.1000106
Copyright: © 2012 Hakkak R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Previously, we reported that obese Zucker rats had increased susceptibility to DMBA-induced mammary tumors compared to lean Zucker rats. In that experiment, 36% of the obese ovariectomized rats developed mammary tumors while lean ovariectomized rats developed no mammary tumors. The obese sham-operated rats developed mammary tumors (59%) compared to 30% of the lean sham-operated rats. On the other hand, several lines of evidence suggest that lower serum selenium (Se) may play an important role in increasing the risk of several types of cancers (e.g., colon, breast and prostate cancers). In the present study, we used this Zucker rat model to examine the effect of obesity on Se status, and the serum Se level was determined by graphite furnace atomic absorption spectrometry. We found that the serum Se levels did not differ by ovariectomy when comparing the combined sham-operated groups with the combined ovariectomized groups; similarly, there was little difference among the four sub-groups. However, obesity decreased the serum Se levels in the combined obese groups (480 ± 10.9 ng/ml) when compared with the combined lean groups (511 ± 10.3 ng/ml) (P<0.05). In summary, our data demonstrate for the first time that obesity decreases serum Se levels in an animal model and suggest that serum Se may play an important role mammary carcinogenesis.

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