Obesity Definition Differences and Association with Coronary Artery Disease in a Rural Malaysia Population
|Aye M1*, Cabot JSF1 and Sazali M2|
|1 Department of Medicine, Melaka Manipal Medical College, Malaysia|
|2 Epidemiologist, State Health Department, Ministry of Health, Perak, Malaysia|
|Corresponding Author :||Aye M
Department of Medicine
Melaka Manipal Medical College, Malaysia
E-mail: [email protected]
|Received March 13, 2014; Accepted March 31, 2014; Published April 07, 2014|
|Citation: Aye M, Cabot JSF, Sazali M (2014) Obesity Definition Differences and Association with Coronary Artery Disease in a Rural Malaysia Population. J Metabolic Synd 3:138. doi:10.4172/2167-0943.1000138|
|Copyright: © 2014 Aye M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Obesity, defined conventionally by Basal Mass Index (BMI), is associated with numerous cardiac complications such as coronary heart disease, heart failure, and sudden death. However, not all obese people are affected by metabolic disturbances and a subset of normal BMI individuals suffer from metabolic syndrome (MetS). Although these phenotypes have been recognized by researchers, there is a paucity of data for obese people without MetS (MHO) (MetS+/Obe-). This study examined the prevalence of different definitions of obesity and their association with Coronary Artery Disease (CAD) in a Malay rural population.
Method: The group, an 18 month cross sectional, hospital based study, comprised 408 patients who were nonsmokers, age 20 and above, both gender and all races. We used differing definitions of obesity based on BMI, the consequences of obesity by these different definitions and ethnic associations.
Results: In patients with BMI ≥ 25, ≥ 27, and ≥ 30, the percentages of MHO were 15.4, 10.8 and 5.7% respectively. Obese, metabolic abnormal groups (MetS+/Obe+) (MOO) defined at BMI ≥ 25 (1.92, CI =1.16-3.17), ≥ 27 (1.94, CI=1.18-3.17) and non-obese, metabolic abnormal group with BMI<30 (MetS+/Obe-) (MONO) (1.71, CI=1.04-2.80) were significantly associated with CAD.
Conclusion: Obese, metabolic abnormal groups (MetS+/Obe+) (with obesity defined as BMI ≥ 25, ≥ 27) and metabolic abnormal group (MetS+/Obe-) with BMI <30 (with obesity defined as BMI ≥ 30) were significantly associated with CAD but obese metabolic normal subjects (Mets+/Obe-) (MHO) with BMI <27 were not significantly associated with CAD.