alexa Obesity: Is it an Independent Risk Factor for Diabetes
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Review Article

Obesity: Is it an Independent Risk Factor for Diabetes and Cancer?

Jalal Hejazi1,2 and Reza Rastmanesh1,2*

1Department of Clinical Nutrition & Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2National Nutrition and Food Sciences Technology Research Institute, Tehran, Iran

Corresponding Author:
Dr. Reza Rastmanesh
Faculty of Nutrition, Arghavane Gharbi
Farahzadi Blvd, Shahrake Gharb
PO Box 19395-4741, Tehran, Iran
Tel: 9821-22357484
Fax: 9821-22360660
E-mail: [email protected]

Received Date: September 13, 2013; Accepted Date: October 08, 2013; Published Date: October 14, 2013

Citation: Hejazi J, Rastmanesh R (2013) Obesity: Is it an Independent Risk Factor for Diabetes and Cancer? J Mol Genet Med S1:002. doi:10.4172/1747-0862.S1-002

Copyright: © 2013 Hejazi J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



Today obesity is known as a causal or a strong risk factor for type 2 diabetes mellitus (T2D) and many of
common cancers; however, is really obesity an independent risk factor for diabetes mellitus and cancer?
Studying the etiology of obesity, T2D and many types of cancers, we can see important common players.
Genetic and epigenetic similarities between the diseases, role of microbiota in their development and progression, effect of life style related factors such as physical activity, diet and etc., are some of these players. Based on these evidences and also with recent identification of metabolically healthy obese individuals, the obese individuals whose mortality and morbidity rate is the same as non-obese people, we can conclude that obesity is not an independent risk factor for diabetes or cancer per se, and it is probably results from the same risk factors as these diseases. In this review we will explain the similarities between pathophysiology of obesity, cancer and diabetes and also coexisting conditions with obesity which may relate to cancer and T2D.

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