Observation of Mean Transit Time (Mtt) Perfusion Maps on a 320-Detector Row Ct Scanner and its Potential Application in Acute Ischemic StrokeHaitham Dababneh1, Waldo Guerrero1, Kelvin Wilson2, Brian L. Hoh2, J Duffy Mocco2, Jeffery Bennett3 and Michael F. Waters1,4*
- Corresponding Author:
- Dr. Michael F. Waters, MD, PhD
Departments of Neurology and Neuroscience
University of Florida College of Medicine
HSC Box 100236 Gainesville, FL
E-mail: [email protected] edu
Received date: June 15, 2011; Accepted July 20, 2011; Published date: July 28, 2011
Citation: Dababneh H, Guerrero W, Wilson K, Hoh BL, Mocco JD, et al. (2011) Observation of Mean Transit Time (Mtt) Perfusion Maps on a 320-Detector Row Ct Scanner and its Potential Application in Acute Ischemic Stroke. J Neurol Neurophysiol 2:117. doi:10.4172/2155-9562.1000115
Copyright: © 2011 Dababneh H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background and Purpose: We present three patients with acute ischemic stroke who underwent computed tomography perfusion (CTP) imaging utilizing an Aquilion ONE (Toshiba Medical Systems, Nasu, Japan) 320-dectector row CT scanner using a Singular Value Decomposition Plus (SVD+) algorithm to generate perfusion maps. These MTT maps may prove to be a sensitive and specific predictor of ischemic penumbra (IP) and infarct core (IC). Methods: Patients, who presented with an acute ischemic stroke, received high quality whole-brain CTP scans and a follow up MRI or non-contrast CT (NCCT) scan, and underwent successful pharmacological and/ or interventional reperfusion procedures were selected for evaluation. A neuroradiologist utilizing Vitrea FX 3.1 software reviewed images, and the IC volumes were calculated. Results: A comparison was made between the volumes of infarct core utilizing SVD+ MTT maps and DWI MR sequences or a sub-acute NCCT. There was a correlation between the infarct core volume measured on MTT and final infarct volume on follow up imaging. However due to limitations associated with a small sample size, a statistical correlation cannot be definitively calculated from this data set. Conclusions: Utilization of the SVD+ MTT map may allow for a more accurate assessment of the infarct core and surrounding salvageable tissue as compared to cerebral blood flow/cerebral blood volume (CBF/CBV) mismatch though further studies are required to validate this observation.