alexa Observation Study of the Retina with the Alzheimers Disease or Amnestic Mild Cognitive Impairment Patients | OMICS International | Abstract
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Research Article

Observation Study of the Retina with the Alzheimers Disease or Amnestic Mild Cognitive Impairment Patients

Yue Wu1, Xiao-Ni Wang2,3, Ningli Wang4, Ying Han2,3 and Yan Lu1,5*
1Department of Ophthalmology, Xuan Wu Hospital of Capital Medical University, Beijing, 100053 China
2Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing, 100053 China
3Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053 China,
4Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, NO.1 Dongjiaominxiang street, Dongcheng District, Beijing, 100730 China
5Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Rd., Yangfangdian, Haidian District, Beijing 100038 China
*Corresponding Author : Yan Lu
Professor, Department of Ophthalmology
Beijing Shijitan Hospital, Capital Medical University
No. 10 Tieyi Rd., Yangfangdian
Haidian District, Beijing 100038, P. R. China
E-mail: [email protected]
Received date: April 04, 2016; Accepted date: April 26, 2016; Published date: April 29, 2016
Citation: Wu Y, Wang X, Wang N, Han Y, Lu Y (2016) Observation Study of the Retina with the Alzheimer’s Disease or Amnestic Mild Cognitive Impairment Patients. J Clin Exp Ophthalmol 7:545. doi:10.4172/2155-9570.1000545
Copyright: © 2016 Wu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: We investigated the regularity changes of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the Alzheimer’s disease (AD) and amnestic Mild Cognitive Impairment (aMCI) patients. Methods: 24 AD patients, 22 aMCI patients and 30 health controls whose age were above 60 years old were recruited in the study. The RNFL thickness and the mGCC average thickness were measured by Fourier-domain optical coherence tomography (FD-OCT). Results: Compared with the controls, we found statistically significant lower of the intraocular pressure (IOP) in the AD and aMCI patients. When compared with the AD patients and controls, aMCI patients showed a significant decrease in RNFL thickness in ST (Superior Temporal), TU (Temporal Upper) and temporal (TU+TL) quadrants. The average thickness of the mGCC was significantly thinner in the aMCI patients than in the AD patients and Controls. The Gross Loss of Volume (GLV) was significantly higher in the aMCI group than in the patients and Controls. Conclusion: AD and aMCI patients had lower IOP, but there was no evidence that IOP would decrease with the progression of disease. Retinal degeneration in the aMCI patients detected by OCT may be a pathological indicator of the disease.

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