Reach Us +1-504-608-2390
Obstructive Sleep Apnea and Lymphocytic Sialadenitis: The Focus isnt Just Sjgrens Syndrome | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Obstructive Sleep Apnea and Lymphocytic Sialadenitis: The Focus isnt Just Sjgrens Syndrome

Ashhad Mahmood1, Jonathan F Lara1# and Elliot D Rosenstein2*
1Department of Pathology, St. Barnabas Medical Center, Livingston, NJ, USA
2Institute for Rheumatic and Autoimmune Diseases, Overlook Medical Center, Summit, NJ, USA
Corresponding Author : Elliot D Rosenstein, MD
Institute for Rheumatic & Autoimmune Diseases
Overlook Medical Center, 33 Overlook Road, Summit, NJ, USA
Tel: 908-598-7940
Fax: 908-598-5447
E-mail: [email protected]
Received: September 25, 2015 Accepted: October 28, 2015 Published: October 30, 2015
Citation: Mahmood A, Lara JF, Rosenstein ED (2015) Obstructive Sleep Apnea and Lymphocytic Sialadenitis: The Focus isn’t Just Sjögren’s Syndrome . J Clin Cell Immunol 6:368. doi:10.4172/2155-9899.1000368
Copyright: © 2015 Mahmood A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google


Objective: We examined the presence of lymphocytic infiltration and measured focus scores in uvular specimens of patients with obstructive sleep apnea (OSA).

Methods: We reviewed the histopathology of 101 uvular specimens obtained from patients with OSA and uvular hypertrophy. A lymphocyte focus score assessment was performed for each case.

Results: Of the 101 cases, 42 (42%) cases had a positive focus score (score ≥ 1). Of those cases with a positive focus score, 22 (52%) had a focus score of 1, 14 (33%) had a focus score of 2, 4 (9%) had a focus score of 3, and 2 (5%) had a focus score of 4. Of the 59 patients (58%) with negative focus scores, 39 (66%) had minor lymphocytic infiltrates; 17 (29%) had features of chronic sialadenitis or extensive fibrosis; 3 (5%) had salivary mucosa without any apparent lymphocytes.

Conclusion: Our findings indicate that patients with OSA may exhibit focal lymphocytic sialadenitis (FLS). It remains to be determined whether mucosal changes occur elsewhere in the oral cavity of patients with OSA. If so, the presence of OSA may complicate the histologic evaluation of Sjögren’s syndrome. Further investigations to determine the prevalence of FLS in the uvulae of individuals without history of OSA, the extent of FLS elsewhere within the oral cavity of patients with OSA and the relationship between the local inflammatory reaction and the systemic consequences of OSA are needed.


Recommended Conferences

7th International Congress on Infectious Diseases

Berlin, Germany

4th International Conference on Mass Spectrometry

Milan, Italy
Share This Page