Obtaining of Hydrogels using PVA and HEC for Adipose Tissue Regeneration
- Corresponding Author:
- Saucedo Acuna Rosa A
Biomedical Institute, Universidad Autonoma de Ciudad Juarez
Anillo envolvente del Pronaf y Estocolmo s/n. CP 32300, Cd Juarez, Chih, Mexico
E-mail: [email protected]
Received date: July 11, 2015; Accepted date: August 07, 2015; Published date: August 14, 2015
Citation: Carrillo KLT, Tamayo G, Donohue A, Kobayashi T, Acuna RAS (2015) Obtaining of Hydrogels using PVA and HEC for Adipose Tissue Regeneration. J Tissue Sci Eng 6:152. doi:10.4172/2157-7552.1000152
Copyright: © 2015 Tovar, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Polyvinyl Alcohol (PVA) and Hydroxy Ethyl Cellulose (HEC) were used to prepare hydrogel for tissue regeneration. Female rabbits were used to evaluate the obtained hydrogels for the regeneration of adipose tissue. Mechanical and biocompatible properties were evaluated. AFM (Atomic Force Microcopy) and SEM (Scanning Electron Microscopy) showed the roughness around 5.447 nm and pore size from 1 to 7.9 μm. In vivo tests were conducted during two years in female rabbits. Histological images showed stable fat formation over long-term without adverse reaction or necrosis. The obtained results indicated that PHEC30 hydrogel may provide a viable approach for the regeneration of adipose tissue in female rabbits as first step as an alternative solution for women who suffered a radical mastectomy.