Occurrence of Metachronous Multiple Malignancies. Review of the Literature: Case of Three Patients
- Corresponding Author:
- Falkenstern Ge RF
Division of Pulmonology
Center for Pulmonology and Thoracic Surgery
Teaching Hospital of the University of Tuebingen
Solitude Str. 18, 70839 Stuttgart- Gerlingen
E-mail: [email protected]
Received March 30, 2016; Accepted April 29, 2016; Published May 02, 2016
Citation: Falkenstern Ge RF, Kimmich M, Wohlleber M, Bode-Erdmann S, Hüttl K, et al. (2016) Occurrence of Metachronous Multiple Malignancies. Review of the Literature: Case of Three Patients. Oncol Cancer Case Rep 2:113. doi:10.4172/2471-8556.1000113
Copyright: © 2016 Falkenstern Ge GF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We report the rare occurrence of multiple metachronous malignancies in three patients within different time frames from 18 months, 7 years and up to 25 years, respectively. Multiple primary malignant neoplasias (MPMN) are extremely rare. The key risk factors may be smoking and family history. While numerous studies have been published on the development of secondary malignancies following a first primary, the literature contains only few reports of patients with multiple metachrounous malignancies.