alexa Ocular Hemodynamic Response to Intravitreal Pegaptanib
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Ocular Hemodynamic Response to Intravitreal Pegaptanib in Eyes with Exudative Age-Related Macular Degeneration

Burak Turgut1*, Murat Kaya1, Sonay Coskun2, Orhan Aydemir1 and Nurettin Deniz1
1Fırat University School of Medicine, Department of Ophthalmology, Elazig, Turkey
2Fırat University School of Medicine, Department of Radiology, Elazig, Turkey
Corresponding Author : Burak Turgut, MD.
Assistant Professor of Ophthalmology
Firat University School of Medicine
Department of Ophthalmology, Elazig, Turkey
Tel: +904242333555
Fax: +904242388096
E-mail: [email protected]
Received July 23, 2010; Accepted September 04, 2010; Published September 04, 2010
Citation: Turgut B, Kaya M, Coskun S, Aydemir O, Deniz N (2010) Ocular Hemodynamic Response to Intravitreal Pegaptanib in Eyes with Exudative Age-Related Macular Degeneration. J Clinic Experiment Ophthalmol 1:109. doi:10.4172/2155-9570.1000109
Copyright: © 2010 Turgut B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google
 

Abstract

Purpose: To assess ocular hemodynamic response to intravitreal pegaptanib in patients with age related macular degeneration (AMD).
 
Methods: Both eyes of twenty patients with choroidal neovascular membrane of at least four MPS (Macular Photocoagulation Study) disc area in one eye due to AMD were undergoing ocular hemodynamic evaluation. Blood flow velocities of both eyes were measured by Color Doppler Ultrasonography (CDU) before and at first, fourth weeks after intravitreal pegaptanib injection and calculated the arterial resistivity indices. The Wilcoxon-signed rank test was used for statistical analysis.
 
Results: In the treated eyes, the mean PSV (Peak Systolic Velocity) of OA (Ophthalmic Artery) increased significantly to a value of 45.37 ± 17.92 at the first (p=0.007), then returned to an insignifi cant value of 42.19 ± 14.35 at the fourth week (p>0.05). The mean PSV of CRA (Central Retinal Artery) increased signifi cantly to a value of 21.59 ± 6.21 at the first week (p=0.12) and, then remained in a significant value of 21.06 ± 4.95 at the fourth week (p=0.006). The mean EDV (End-Diastolic Velocity) of CRA increased significantly to a value of 6.07 ± 2.30 at the first week (p=0.001) and, then remained in a significant value of 6.20 ± 2.24 at the fourth week (p= 0.001). The mean PSV of PCA (Posterior Ciliary Artery) increased significantly to a value of 30.66 ± 10.73 at the first week in comparison to the value of at the fourth week (p=0.038). However, there was no significantly difference with value of 26.57 ± 5.91 at the fourth week (p>0.05), when compared with pretreatment measurement (27.60 ± 7.84). CDU measurements in untreated eyes did not show any significant change following and before the injection.
 
Conclusion: Resistivity indices of CRA, PCA and OA were not altered following intravitreal pegaptanib as an anti- VEGF agent in patients with AMD.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

g[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords