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Ocular Manifestations of Systemic Lupus Erythematosus | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Ocular Manifestations of Systemic Lupus Erythematosus

Asima Bajwa1,2 and Stephen C Foster1,2,3*
1Massachusetts Eye Research and Surgery Institution (MERSI), 5 Cambridge Center, 8th Floor, Cambridge, MA 02142, USA
2Ocular Immunology and Uveitis Foundation (OIUF), 5 Cambridge Center, 8th Floor, Cambridge, MA 02142, USA
3Harvard Medical School, Boston, MA, USA
Corresponding Author : Stephen C Foster
Massachusetts Eye Research and Surgery Institution (MERSI)
5 Cambridge Center, 8th Floor, Cambridge, MA 02142, USA
Tel: 617 621 6377
Fax: 617 494 1430
E-mail: [email protected]
Received December 20, 2013; Accepted February 24, 2014; Published February 28, 2014
Citation: Bajwa A, Foster CS (2014) Ocular Manifestations of Systemic Lupus Erythematosus. J Clin Cell Immunol 5:191. doi: 10.4172/2155-9899.1000191
Copyright: © 2014 Bajwa, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of numerous antibodies that may affect multiple organ systems. Wide variety of systemic features of SLE are attributed to antibodies against the components of cell nuclei. Many of the clinical features, like nephritis and arthritis are due to deposition of immune complexes resulting in tissue damage. Other features of the disease such as hemolytic anemia, thrombocytopenia is due to direct effect of autoantibodies. The ocular manifestations of SLE include lid dermatitis, keratitis, scleritis, secondary Sjogrens syndrome, retinal and choroidal vascular lesions and neuroophthalmic lesions. Keratoconjunctivitis sicca is the most common ocular manifestation, but visual morbidity is usually due to retinal and neuro-ophthalmic manifestations of the disease. Ocular involvement may precede systemic onset of the disease. Early recognition of ocular disease by an ophthalmologist may prevent not only the blinding complications of SLE but also alert the clinician to the likely presence of disease activity elsewhere and timely institution of systemic therapy.