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Olive Leaf Extract as a New Topical Management for Oral Mucositis Following Chemotherapy: A Microbiological Examination, Experimental Animal Study and Clinical Trial | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Olive Leaf Extract as a New Topical Management for Oral Mucositis Following Chemotherapy: A Microbiological Examination, Experimental Animal Study and Clinical Trial

Khadija Muhamed Ahmed1,Nazar Talabani1 and Tagreed Altaei2*

1College of Dentistry,University of Sulaimani,Iraq

2Department of Pharmacology and Toxicology,College of Pharmacy,Hawler Medical University, Iraq

*Corresponding Author:
Tagreed Altaei D
Assistant Professor, Department of Pharmacology and Toxicology
College of Pharmacy, Hawler Medical University, Iraq
Tel: 00964 750 4941834
E-mail: [email protected]

Received date: July 02, 2013; Accepted date: September 26, 2013; Published date: September 30, 2013

Citation: Ahmed KM, Talabani N, Altaei T (2013) Olive Leaf Extract as a New Topical Management for Oral Mucositis Following Chemotherapy: A Microbiological Examination, Experimental Animal Study and Clinical Trial. Pharmaceut Anal Acta 4:269. doi: 10.4172/2153-2435.1000269

Copyright: © 2013 Ahmed KM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Oral mucositis is a common complication of intensive cancer chemotherapy and radiotherapy. Olive leaf extract was investigated through microbiological, experimental animal studies and clinical trial. The results were compared with the action of benzydamine HCl as positive control and normal saline as negative control.

Thirty patients under intensive chemotherapeutic treatment were included in the microbiological part of the study for assessment of the oral flora changes, and the antimicrobial activity of olive leaf and benzydamine HCl against preisolated microoganisms were studied. Oral mucositis was induced through a combination of systemic administration of 5-fluorouracil as chemotherapeutic agent and mild abrasion of the left buccal mucosa of Forty-five male albino rats. An evaluation of the healed buccal mucosa was performed histologically under light microscope at days 7, 9 and 14 of the experiments. In the clinical part of the study, 62 cancer patients receiving intensive chemotherapy were randomized to receive olive leaf extract, benzydamine HCl or placebo local treatment for two weeks in a three period crossover design. WHO toxicity grading and OMAS mucositis score were applied at days 1, 8 and 15 of each cycle.

In Conclusion; olive leaf extract was effective in reducing the incidence and decreasing the severity of oral mucositis when compared to benzydamine HCl and placebo groups. Accordingly we suggest using this medication for oral mucositis as a safe (herbal) and effective treatment modality.

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